The US actress beat out 200 people to win the coveted role as Minnie Mouse back in 1986.
She also lent her voice to other characters in numerous films and TV shows, including Who Framed Roger Rabit and Micky Mouse Clubhouse.
Bob Iger, chairman, and chief executive of Disney said: “Minnie Mouse lost her voice with the passing of Russi Taylor.
“We’re so grateful for Russi’s talent as well as the tremendous spirit and great joy she brought to everything she did.
“It was a privilege to have known her and an honour to have worked with her, and we take comfort in the knowledge that her work will continue to entertain and inspire for generations.”
Taylor found her real-life Mickey in the form of Wayne Allwine, who had voiced the famous mouse since 1997.
“It was a privilege to have known her and an honour to have worked with her”- Bob Iger
They married in 1991 and remained as inseparable as their animated counterparts until Allwine’s death in 2009.
Taylor had been a huge Disney fan since her childhood and even met Walt Disney when she was a young girl.
Bill Farmer, the voice of Goofy, said he would “dearly miss” his long-time friend.
As well as Minnie, Taylor also voiced the roles of Huey, Dewey and Louie and their pal Webbigail Vanderquack, in the original DuckTales animated series.